Our new Distinct+ tissue clearing method is the sole strategy that delipidates samples without improve in morphology and with minimal impact on structural integrity.
Megatome is actually a vibrating microtome intended to part a wide number of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With high blade vibrating frequency and minimized blade deflection, Megatome enables substantial-throughput tissue sectioning with uniform floor profile, together with negligible tissue destruction and information loss.
Antibodies may take weeks to diffuse by way of just a few millimeters of tissue, by using a steep labeling gradient from floor to core.
Megatome is made for accuracy: the blade vibrates at a greater frequency and larger amplitude variety than other microtomes, and includes a exclusive deflection Management system.
SE works by using a rotational electrical discipline to disperse very electromobile molecules (like antibodies or surfactant micelles) throughout a porous sample without harming electrically billed constructions inside the tissue. This enables two-four day clearing of intact organs,
Our preformulated EasyIndex Resolution raises and homogenize the refractive index of delipidated tissue samples, rendering them entirely transparent. This enables light-weight penetration in the sample and guarantees the acquisition of significant-resolution, in-target image data.
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It’s the perfect time to update your microtome to Megatome. With accurate substantial-frequency slicing for an unmatched selection of sample dimensions and types – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for varied programs.
Entirely delipidate megatomi.com total mouse brains or comparably sized samples in just one working day with SmartBatch+, or in one 7 days with our passive clearing kit.
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Leverage the Crystal clear+ tissue clearing process, along with eFLASH and patented stochastic electrotransport technologies, to speedily crystal clear and label whole organs. Important highlights and functions include things like:
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